June 1, 2020
COTA Team

Real-World Evidence Provides Insights Into the Effectiveness of Hydroxychloroquine and Tocilizumab for Treating COVID-19 – New Findings Published

COTA, in collaboration with Hackensack Meridian Health (HMH), New Jersey’s largest and most comprehensive health network, and Berry Consultants recently conducted a study using real-world evidence (RWE) to determine the effectiveness of hydroxychloroquine and tocilizumab to treat COVID-19. The study used real-world data (RWD) from HMH’s RE-COV-RY database, which is one of the biggest collections of hospital-based COVID-19 data in the United States representing more than 3,000 patients hospitalized with COVID-19. 

The study concluded hydroxychloroquine does not improve survival for patients hospitalized with COVID-19. It was also found that another drug, tocilizumab, may improve survival among critically ill intensive care unit patients. With this information, and if the results are confirmed through additional research, tocilizumab would become one of the first medications that can improve survival from COVID-19. Randomized clinical trials will be needed to determine the efficacy of these drugs, however, this real-world observational study offers initial insights into potentially effective treatment strategies for COVID-19.

Among 2,512 hospitalized patients with COVID-19, 76% of patients received at least one dose of hydroxychloroquine and 59% received hydroxychloroquine with azithromycin. The results from the study found that there were no significant differences in associated mortality for patients receiving any hydroxychloroquine during the hospital stay. Similarly, an exploratory analysis among 547 ICU patients, including 134 receiving tocilizumab, found a trend towards an improved survival rate, with 56% who received the drug compared to 46% who did not.

“We are pleased that our ongoing collaboration and expertise in RWD and analytics capabilities are continuing to help advance important research into effective treatments for COVID-19,” said Michael Doyle, COTA President and CEO. “As research into this disease continues and the healthcare industry realizes the importance of cross-industry partnerships, COTA will continue to provide critical insights that will directly impact the treatment options of patients affected by COVID-19.”

Previously, the collaboration’s findings have shown that hypertension, the most common coexisting condition, does not have a major impact on survival from the disease when adjusted for age and other comorbid conditions. 

Read the full findings linked here.


Next Article:
COTA Collaborates to Understand COVID-19 Using Real-World Evidence - New Findings Published
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